Transforming growth factor -1 (TGF-1) is a secreted signaling protein that directs many cellular processes and is an attractive target for the treatment of several diseases. This study looks at the regulatory mechanism of TGF-1 and is of fundamental importance for therapeutic development. The study was published in a paper entitled “Structural insights into conformational switching in latency-associated peptide between transforming growth factor β-1 bound and unbound states” in IUCrJ with the structural model and data in the PDB as entry 6P7J. A combination of crystallographic and small-angle X-ray scattering approaches was used with the solution data deposited as SASDFD2.
Conformational switching in TGFβ-1 (animation)
