Careers at the Institute

The Hauptman-Woodward Medical Research Institute attracts talented scientists by providing exciting research opportunities and the freedom to pursue the unknown.

We offer an excellent benefit package including health insurance, generous retirement plan, disability and life insurance coverage, competitive vacation/holiday policies, and pre-tax spending accounts.

Imagine yourself in a dynamic environment utilizing cutting-edge techniques advancing science for generations.


Current Openings

Cryo-EM Center Director

The Hauptman-Woodward Medical Research Institute is establishing a regional cryo-EM center and is seeking a center director. The HWI center director will be responsible for operational, scientific, and strategic oversight, including growth of the facility, and implementing a robust and reliable cryo-EM imaging pipeline. The pipeline is part of the Center for Therapeutic Interactions being created at the Institute aimed at both the study of interactions and creating them with local, regional and international institutions and biotech industry. We expect a broad spectrum of projects with a wide range of expertise levels. The center director reports directly to the HWI CEO.


Supervise the creation of a state-of-the-art cryo-EM facility within the Institute and create an efficient research and service facility.
• Develop platform that enables inexperienced users to address key scientific questions.
• Establish a sample preparation pipeline for experienced and inexperienced users alike.
• Collaborate with the Business Development Director to attract and retain profitable academic and commercial users for the center.
• Collaborate with complementary resources including a high-throughput crystallization center, synchrotron facilities, and a regional center for computational resources.
• Ensure instrumentation is operational and produces data of the highest possible quality.
• Lead the planning for expansion of the facility to include additional microscopes.
• Attract and retain research staff to help operate the facility.
• Liaise with financial and accounting staff to implement an effective charging scheme for microscope time.
• Advocate for and collaborate on cryo-EM applications within the research community.
• Participate in external funding applications, e.g. instrumentation grants, large-scale center grants, collaborative grant applications, and others.
• Create and implement training programs that promote the scientific and commercial program of research capable on the cryo-EM instrument.
• Communicate with vendors and engineers for maintenance and upgrade of equipment.

Proven expertise in cryo-EM operation and use is required. Organizational skills, and strong written and oral communication abilities, are essential. Applicants will be encouraged to develop their own research program and collaborate closely with Institute scientists. Candidates are expected to have a PhD in a relevant field and a strong record of scientific productivity.

The Institute has a generous benefits package including fully covered health insurance, life insurance and parking. In addition we offer affordable vision and dental plans as well as Flexible spending and dependent care accounts. The Institute offers a retirement plan.

About HWI and Buffalo, NY:
HWI has celebrated more than 60 years as an independent research institute and is continually growing. Located in Buffalo, New York, HWI is at the heart of the growing Buffalo Niagara Medical Campus and partners with the University at Buffalo, Roswell Park Comprehensive Cancer Center, University of Rochester and numerous others. It also has links to industry and operates the IMCA-CAT beamline at the Advanced Photon Source outside of Chicago.
Buffalo offers a vast array of community organizations which add to the richness of the area and also offer people many opportunities to grow and contribute. Housing is one of the most affordable in the United States.  

To Apply:

Please send an introductory e-mail, CV and names of 3 references to Jill Szczesek, HWI Chief Operating Officer at

Synchrotron Macromolecular Crystallographer

The Industrial Macromolecular Crystallography Association – Collaborative Access Team (IMCA‑CAT) and the Hauptman-Woodward Medical Research Institute (HWI) seek an inventive macromolecular crystallographer to join the IMCA‑CAT team in accelerating pharmaceutical drug discovery through synchrotron-based structural biology research. As an employee of HWI, you will be based at the center of the team’s operations at the Advanced Photon Source (APS), Argonne National Laboratory, near Chicago, IL. This is an ideal position for a motivated scientist who is passionate about delivering strategic value, developing new technologies, and working in a high-powered, collaborative environment.

Position Description:

This is an exciting time to join IMCA‑CAT. Underway this summer is the first of a two-phase upgrade that will significantly increase throughput and establish a strong foundation upon which to build capacity. The second phase upgrade, currently in design, will profoundly increase capacity and dramatically expand capability for challenging research projects.

The successful candidate will be an integral part of these upgrade activities while maintaining flow of diffraction data for pharmaceutical research projects. The candidate will work closely with IMCA‑CAT colleagues in an inclusive and respectful environment, and is expected to take initiative and contribute to the team effort.

On any given day, you will do one or all of these things:

  • Contribute to drug discovery research efforts using a growing portfolio of synchrotron sources.
  • Enhance the structural biology programs for pharmaceutical structure-based drug design.
  • Provide experiment support for scientists from the structural biology community who conduct research using the IMCA‑CAT synchrotron beamlines.
  • Ensure beamline instrumentation is operational and produces data of the highest quality.
  • Expand the experiment envelope of the beamline.
  • Establish efficient protocols for accelerating data acquisition while enhancing data security.
  • Develop automated methods for acquiring quality data from challenging samples.
  • Participate in highly collaborative working groups.
  • Engage in the technical development of new strategies for ultra-high throughput.
  • Collaborate with staff on strategically-aligned research and development projects.
  • Communicate with researchers and present at meetings.
  • Conduct independent and/or collaborative research.

Desired Skills and Experience:

  • PhD in a relevant field.
  • Expertise in macromolecular crystallography.
  • Outstanding experimental skills.
  • Considerable mechanical skills.
  • Highly collaborative and team-oriented approach to conducting work and solving problems.
  • Excellent written and oral communication skills.
  • Deeply proactive approach to meeting and exceeding goals.
  • Ability to meet requirements for site access to Argonne National Laboratory.

To Apply:

Send an introductory email, cv, and contact information for three references to Lisa Keefe, IMCA‑CAT Director and HWI Vice President of Advancing Therapeutics at keefe@imca‑

Learn More:

Visit our websites to learn more about IMCA-CAT ( and HWI (

 EEO Statement

The Hauptman-Woodward Medical Research Institute, Inc. (HWI) as an equal opportunity employer, extends employment opportunities to qualified applicants and employees on a non-discriminatory basis without regard to race, color, sex, creed, age, religion, national origin, marital status, veteran status, sexual orientation, genetic predisposition, carrier status, or disability that would prevent the performance of the essential requirements of the job with or without a reasonable accommodation in compliance with the appropriate New York State and Federal laws, or any other legally protected characteristics. This policy applies to all conditions and terms of employment.