The Crystallization Center at HWI
NEWS
HWI Officially Joins the University at Buffalo
Hauptman-Woodward Medical Research Institute (HWI) formally joined the University at Buffalo on Jan. 2 after the two entities finalized the legal transfer of HWI assets to the university. The move, which commenced in May, places the nearly 70-year-old institute and its building on the Buffalo Niagara Medical Campus within the university’s research and educational ecosystems. Specializing in structural biology research that is critical to understanding and treating disease, the institute is now known as the University at Buffalo Hauptman-Woodward Research Institute (UB-HWI).
RESEARCH
Dr. Martynowycz publishes in Nature Protocols
Tiny crystals, big impact! A new Nature Protocols guide by scientists including Dr. Michael Martynowycz, who is now part of HWI, helps others unlock the secrets of molecules using MicroED, a powerful cryoEM technique. The paper describes how to prepare samples, from proteins to small molecules, for this cutting-edge method.
RESEARCH
Dr. Martynowycz publishes in Nature Communications
A new study on how viruses assemble and replicate, by researchers from HWI, UCLA, and HHMI, reveals how viruses hijack cellular condensates to assemble and replicate. The team visualized mammalian reovirus factories, offering unprecedented insights into the molecular sociology of viral replication and assembly.
NEWS
We’re hiring in Buffalo and Chicago
Positions are available in the Snell laboratory for a research technician in Buffalo New York. Click here for details.
We offer an excellent benefits package and a welcoming environment that embraces diversity in people as well as the skills they bring to us
RESEARCH
Drs. Que and Gewirth Publish in Proteins
Drs. Nanette Que and Dan Gewirth at the Hauptman-Woodward Medical Research Institute have published a paper in Proteins: Structure, Function, and Bioinformatics analyzing how drugs bind selectively to a protein that is an emerging therapeutic target for cancer and other diseases.
NEWS
Department of Energy three-year grant for AI-assisted biomedical research
The U.S. Department of Energy has awarded $1.5 million to a joint Hauptman-Woodward Medical Research Institute and University at Buffalo research project that will use artificial intelligence to study how cells and molecules respond to low doses of radiation. Dr. Edward Snell, Hauptman-Woodward Medical Research Institute, and Dominic Sellitto, UB School of Management, serve as investigators on the research.
NEWS
HWI to join UB, strengthening medical science research and education in WNY
The move will bolster health, well-being and innovation in Buffalo Niagara and beyond
Hauptman-Woodward Medical Research Institute will join the University at Buffalo, a move designed to strengthen the two organizations’ joint mission to advance medical science research and education in Western New York and beyond. Read the full press release by clicking here
NEWS
HWI Scientist Daniel Gewirth receives NIH Grant Award
Hauptman-Woodward Medical Research Institute Investigator Daniel Gewirth, PhD, has recently been awarded a four-year, $1.6 million grant from the National Institute of General Medical Sciences (NIGMS) of the The National Institutes of Health.
NEWS
Dr. Bowman Elected as New Fellow of the American Crystallographic Association
Congratulations to Sarah EJ Bowman for being elected as a Fellow of the American Crystallographic Association – the Structural Science Society. The ACA Fellows program recognizes a wealth of knowledge, experience and passion for structural science. ACA Fellows serve as scientific ambassadors to the broader scientific community and the general public to advance science education, research, knowledge, interaction, and collaboration.
RESEARCH
HWI Scientists Published in in Cell Press Cell Reports Physical Science
A team of Hauptman-Woodward Medical Research Institute scientists have a new publication in Cell Press Cell Reports Physical Science.
NEWS
Dr. Keefe Elected to Board of the AIP
Dr. Lisa J. Keefe has been elected by the Council of the American Crystallographic Association (ACA) to serve as a director on the Board of Directors of the American Institute of Physics (AIP).
RESEARCH
Dr. Bowman Publishes in Acta Crystallographica C
Last November, Hauptman-Woodward Medical Research Institute scientist Sarah EJ Bowman, the director of the National Crystallization Center, was an invited speaker and participant in the Electron Diffraction Symposium and Workshop at the National Center for CryoEM Access and Training at the New York Structural Biology Center. The symposium resulted in a recently published paper in the journal Acta Crystallographica C, Structural Chemistry, entitled “Applying 3D ED/MicroED workflows toward the next frontiers“.
RESEARCH
Dr. Lynch Publishes in Biophysical Journal
Miranda Lynch at Hauptman-Woodward Medical Research Institute and a team led by collaborator Gregory Babbitt at Rochester Institute of Technology have just published a paper in Biophysical Journal describing ATOMDANCE. Read the paper by clicking here.
NEWS
Hauptman-Woodward Institute Scientist Participates in Study of Protein Folding Mechanisms
Dr. Daniel Gewirth, an Investigator at HWI, has participated in a study that examined the way in which proteins are activated in the human body. The collaborative study, published in the prestigious journal, Proceedings of the National Academy of Science, showed how helper proteins, called chaperones, collaborate with each other to achieve the folded state of their client proteins. Read the full paper by clicking here.
RESEARCH
Dr. Paz publishes in Nature Communications
HWI scientist Dr. Aviv Paz was part of a team that published a paper entitled “Membrane potential accelerates sugar uptake by stabilizing the outward-facing conformation of the Na/glucose symporter vSGLT” in the journal Nature Communications. This work with scientists at the University of California Los Angeles and San Francisco has broad implications for transporting numerous chemicals in the body and managing life-threatening conditions like diabetes, heart failure, and kidney failure.