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Brewing Science

A beer tasting to benefit the Hauptman-Woodward Medical Research Institute.

Thursday, June 20, 2024 | 5:30 – 8:00 PM

The Crystallization Center at HWI

NEWS

HWI Scientists Published in in Cell Press Cell Reports Physical Science

A team of Hauptman-Woodward Medical Research Institute scientists have a new publication in Cell Press Cell Reports Physical Science.

NEWS

HWI to join UB, strengthening medical science research and education in WNY

The move will bolster health, well-being and innovation in Buffalo Niagara and beyond

BUFFALO, N.Y. – Hauptman-Woodward Medical Research Institute will join the University at Buffalo, a move designed to strengthen the two organizations’ joint mission to advance medical science research and education in Western New York and beyond.

Read the full press release here: https://www.buffalo.edu/news/releases/2024/05/ub-hwi.htmlhttps://lnkd.in/e-cNe87H

NEWS

Dr. Keefe Elected to Board of the AIP

Dr. Lisa J. Keefe has been elected by the Council of the American Crystallographic Association (ACA) to serve as a director on the Board of Directors of the American Institute of Physics (AIP).

Congratulations to Dr. Keefe on this appointment and on being a recognized leader in the community.

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NEWS

We’re hiring in Buffalo

Positions are available a Postdoctoral researcher and  a scientist in Buffalo New York. Click here for details.

We offer an excellent benefits package and a welcoming environment that embraces diversity in people as well as the skills they bring to us

NEWS

Dr. Bowman Publishes in Acta Crystallographica C

Last November, Hauptman-Woodward Medical Research Institute scientist Sarah EJ Bowman, the director of the National Crystallization Center, was an invited speaker and participant in the Electron Diffraction Symposium and Workshop at the National Center for CryoEM Access and Training at the New York Structural Biology Center. The symposium resulted in a recently published paper in the journal Acta Crystallographica C, Structural Chemistry, entitled “Applying 3D ED/MicroED workflows toward the next frontiers.

RESEARCH

Dr. Lynch Publishes in Biophysical Journal

Miranda Lynch at Hauptman-Woodward Medical Research Institute and a team led by collaborator Gregory Babbitt at Rochester Institute of Technology have just published a paper in Biophysical Journal describing ATOMDANCE.

Read the paper by visiting: https://authors.elsevier.com/c/1isgh1SPT7sJw

Image of HWI Young Professionals Recruitment for 2024

NEWS

Hauptman-Woodward Institute Scientist Participates in Study of Protein Folding Mechanisms

Dr. Daniel Gewirth, an Investigator at HWI, has participated in a study that examined the way in which proteins are activated in the human body. The collaborative study, published in the prestigious journal, Proceedings of the National Academy of Science, showed how helper proteins, called chaperones, collaborate with each other to achieve the folded state of their client proteins.

Read the full paper by clicking here

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RESEARCH

Dr. Paz publishes in Nature Communications 

HWI scientist Dr. Aviv Paz was part of a team that published a paper entitled “Membrane potential accelerates sugar uptake by stabilizing the outward-facing conformation of the Na/glucose symporter vSGLT” in the journal Nature Communications. This work with scientists at the University of California Los Angeles and San Francisco has broad implications for transporting numerous chemicals in the body and managing life-threatening conditions like diabetes, heart failure, and kidney failure.

RESEARCH

Dr. Lynch is fighting drug resistance in HIV/AIDS

Around the world, HIV/AIDS continues to be a major health problem. Several treatment regimens have dramatically reduced HIV-related illness and death. HIV-1 protease is one of the critical targets of these regimens. However, this drug target is prone to the development of treatment resistance. HWI scientist Dr. Miranda Lynch and collaborators at the Rochester Institute of Technology recently published this research in Biophysics Reports in a paper entitled Evolution of drug resistance drives destabilization of flap region dynamics in HIV-1 protease.

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NEWS

Dr. Snell joins the IUCr Book Series Committee

Dr. Edward Snell, Chief Scientific Officer at Hauptman-Woodward Medical Research Institute (HWI), has been appointed to the International Union of Crystallography (IUCr) Committee as a member of the Book Series Committee. The Committee recommends new book publications to the IUCr Executive Committee and the Delegates of Oxford University Press. Recommended publications are IUCr monographs, which are in-depth expositions of specialized topics in crystallography, crystallography texts providing standardized methods and approaches, and related books.

Photo of Dr. Lisa J. Keefe and Dr. Sarah Bowman

NEWS

Drs. Keefe and Bowman Elected to US National Committee for Crystallography

We congratulate both Dr. Lisa Keefe for being elected as the new Vice Chair and Dr. Sarah Bowman for being elected as a member of the US National Committee for Crystallography (USNC/Cr).

Research

HWI scientists Miranda Lynch, Elizabeth Snell, Stephen Potter, Edward Snell, and Sarah Bowman published a paper describing crystallization screening at HWI for the worldwide scientific community. The paper entitled 20 years of crystal hits: progress and promise in ultrahigh-throughput crystallization screening was selected as a cover feature.

NEWS

Dr. Sarah EJ Bowman and Dr. Miranda L Lynch have received a new $1.57M grant from the National Institutes of Health.

A  $1.57M grant from the National Institutes of Health to supports research on detecting and handling small crystals for cutting edge structural biology. Structural characterization of biomolecules important in human health and disease is crucial to understanding how these molecules function, as well as to designing therapeutics. Structural methods that make use of vanishingly small crystals have the potential to revolutionize how we obtain highly detailed structural ‘snapshots’ of biomolecules.

COVID-19 image from CDC to show the individual proteins making up the structure of the virus

News

The Institute is home to the National Crystallization Center

This Five-year award from NIH brings prestige, jobs, investment to Western New York and recognizes almost two decades of our developments in this area. The National Crystallization Center provides access to state-of-the-art robotic instrumentation, advanced imaging technologies, and expertise in crystallization to the scientific community supporting both academia and industry.

The Center is actively involved in the fight against COVID-19.

Cryo-EM Banner

Take a closer look at HWI’s world-class Cryo-EM center.