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The Crystallization Center at HWI

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NEWS

Apply for the HWI Young Professionals 2024 Program Today!

HWI Young Professionals is a six-session program that engages young professionals focused on building community support for the Hauptman-Woodward Medical Research Institute.

To apply or to learn more, please visit our Young Professionals page or contact Kelly Campbell at kcampbell@hwi.buffalo.edu or (716) 898-8624.

Institute

Structures Magazine

Fall 2023 / Winter 2024 Edition.

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NEWS

We’re hiring

Positions available for Scientists, and a Business Development Manager in Buffalo New York. Click here for details.

We offer an excellent benefits package and a welcoming environment that embraces diversity in people as well as the skills they bring to us

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RESEARCH

Dr. Paz publishes in Nature Communications 

HWI scientist Dr. Aviv Paz was part of a team that published a paper entitled “Membrane potential accelerates sugar uptake by stabilizing the outward-facing conformation of the Na/glucose symporter vSGLT” in the journal Nature Communications. This work with scientists at the University of California Los Angeles and San Francisco has broad implications for transporting numerous chemicals in the body and managing life-threatening conditions like diabetes, heart failure, and kidney failure.

RESEARCH

Dr. Lynch is fighting drug resistance in HIV/AIDS

Around the world, HIV/AIDS continues to be a major health problem. Several treatment regimens have dramatically reduced HIV-related illness and death. HIV-1 protease is one of the critical targets of these regimens. However, this drug target is prone to the development of treatment resistance. HWI scientist Dr. Miranda Lynch and collaborators at the Rochester Institute of Technology recently published this research in Biophysics Reports in a paper entitled Evolution of drug resistance drives destabilization of flap region dynamics in HIV-1 protease.

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NEWS

Dr. Snell joins the IUCr Book Series Committee

Dr. Edward Snell, Chief Scientific Officer at Hauptman-Woodward Medical Research Institute (HWI), has been appointed to the International Union of Crystallography (IUCr) Committee as a member of the Book Series Committee. The Committee recommends new book publications to the IUCr Executive Committee and the Delegates of Oxford University Press. Recommended publications are IUCr monographs, which are in-depth expositions of specialized topics in crystallography, crystallography texts providing standardized methods and approaches, and related books.

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NEWS

Drs. Keefe and Bowman Elected to US National Committee for Crystallography

We congratulate both Dr. Lisa Keefe for being elected as the new Vice Chair and Dr. Sarah Bowman for being elected as a member of the US National Committee for Crystallography (USNC/Cr).

Research

HWI scientists Miranda Lynch, Elizabeth Snell, Stephen Potter, Edward Snell, and Sarah Bowman published a paper describing crystallization screening at HWI for the worldwide scientific community. The paper entitled 20 years of crystal hits: progress and promise in ultrahigh-throughput crystallization screening was selected as a cover feature.

RESEARCH

Dr. Sarah EJ Bowman and the National Crystallization Center help address the challenge of finding new antimicrobials

HWI has been involved in a large collaborative project resulting in a paper published in Nature Microbiology.

NEWS

Dr. Sarah EJ Bowman and Dr. Miranda L Lynch have received a new $1.57M grant from the National Institutes of Health.

A  $1.57M grant from the National Institutes of Health to supports research on detecting and handling small crystals for cutting edge structural biology. Structural characterization of biomolecules important in human health and disease is crucial to understanding how these molecules function, as well as to designing therapeutics. Structural methods that make use of vanishingly small crystals have the potential to revolutionize how we obtain highly detailed structural ‘snapshots’ of biomolecules.

COVID-19 image from CDC to show the individual proteins making up the structure of the virus

News

HWI staff in Chicago help Pfizer create an effective COVID-19 treatment

Our team at the Advanced Photon Source have helped Pfizer create a COVID-19 treatment. The new drug candidate, Paxlovid, significantly reduced hospitalization and death in adult patients, according to Pfizer, and will be submitted for an emergency use authorization in the United States. 

COVID-19 image from CDC to show the individual proteins making up the structure of the virus

News

The Institute is home to the National Crystallization Center

This Five-year award from NIH brings prestige, jobs, investment to Western New York and recognizes almost two decades of our developments in this area. The National Crystallization Center provides access to state-of-the-art robotic instrumentation, advanced imaging technologies, and expertise in crystallization to the scientific community supporting both academia and industry.

The Center is actively involved in the fight against COVID-19.

Research

Dr. Snell accuratly identifying metals in proteins.
Many proteins contain metals. Accurate identification of these is both a problem and a prerequisite to understanding the biological mechanism and curing disease. An international team co-led by Dr. Snell developed a
 sensitive method to accurately determine both the metal type and position using very small volumes of protein.

COVID-19 image from CDC to show the individual proteins making up the structure of the virus

Research

Structural biology at the center of COVID-19 scientific efforts

Synergy between X-ray crystallography, cryoelectron microscopy and computational methods has led to critical advances indispensable to developing treatments for infection and vaccines for prevention.

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Take a closer look at HWI’s world-class Cryo-EM center.