Conformational switching in TGFβ-1 (animation)

Conformational switching in TGFβ-1 (animation)

Transforming growth factor -1 (TGF-1) is a secreted signaling protein that directs many cellular processes and is an attractive target for the treatment of several diseases. This study looks at the regulatory mechanism of TGF-1 and is of fundamental importance for...
Radiation damage in metalloprotein structures

Radiation damage in metalloprotein structures

Xylose isomerase (XI) is an industrially important metalloprotein studied for decades. Its reaction mechanism has been postulated to involve the movement of the catalytic metal cofactor to several different conformations. Here, a dose-dependent approach was used to...