by Jeff Surdej | May 4, 2021 | HWI News, Snell-lab
The COVID-19 pandemic has impacted almost every aspect of our lives in the past year and continues to do so. In March, at the one-year mark of the World Health Organization declaration that COVID-19 is a pandemic, researchers at HWI – Drs. Miranda Lynch, Edward Snell...
by Edward Snell | Nov 17, 2020 | HWI News, Snell-lab
A significant problem in biological X-ray crystallography is the radiation chemistry caused by the incident X-ray beam. This produces both global and site-specific damage. Site-specific damage can misdirect the biological interpretation of the structural models...
by Edward Snell | Jul 31, 2020 | Snell-lab
Dr. Timothy Stachowski, defended his Ph.D. thesis entitled “Towards Understanding the Structural Impact from Therapeutic Radiation Doses from Mechanisms in Engineered Systems to to TGF-β1”. Dr. Stachowski was a Biophysics Ph.D. student in the Snell...
by Edward Snell | Mar 1, 2020 | Snell-lab
Transforming growth factor -1 (TGF-1) is a secreted signaling protein that directs many cellular processes and is an attractive target for the treatment of several diseases. This study looks at the regulatory mechanism of TGF-1 and is of fundamental importance for...
by Edward Snell | Jan 8, 2020 | Snell-lab
Metalloproteins play a key role in the progression of many diseases. Using ion beam analysis through particle-induced X-ray emission (PIXE) and anomalous X-ray analysis we have quantitatively identified the metal atoms in 30 previously structurally...
by Edward Snell | Jul 1, 2019 | Snell-lab
Xylose isomerase (XI) is an industrially important metalloprotein studied for decades. Its reaction mechanism has been postulated to involve the movement of the catalytic metal cofactor to several different conformations. Here, a dose-dependent approach was used to...
