Scientists, including Dr. Michael Martynowycz, who is now part of HWI, have developed a new, detailed guide to help researchers study the tiniest crystals using a technique called Microcrystal Electron Diffraction (MicroED). This work entitled, Comprehensive microcrystal electron diffraction sample preparation for cryo-EM, and published in Nature Protocols, was conducted before Dr. Martynowycz joined HWI, but it reflects his expertise in this cutting-edge area. MicroED allows researchers to see the structure of molecules in incredible detail, which is important for understanding how things like proteins and drugs work. The guide explains how to prepare different types of samples for MicroED, making it easier for scientists to use this powerful tool. This is significant because knowing the shape of molecules helps us design better medicines, understand diseases, and even create new materials. By simplifying complex procedures, this guide will accelerate discovery in various fields of science.