Proteins, by nature are very flexible and dynamic molecular machines. For roughly a century, crystallographers have studied the properties of proteins using crystallized molecules. This often produces static images, a snapshot of the molecule in motion. Dr. Bauer, in collaboration with scientists in the BioXFEL Center, the HWI Dynamics Group (link) and UB, is working to develop methods to studies important proteins in motion. In addition to Dr. Bauer's scientific roles, he is also responsible for educating future generations of researchers as the Associate Education and Diversity Director of BioXFEL. The BioXFEL Science and Technology Center Education program provides young scientists internships opportunities, scholarships, professional development activities and several online educational tools.
The importance of protein dynamics is often overlooked in the field of crystallography as it is difficult to study using conventional methods. By studying the role of protein dynamics, we can develop a better understanding of how proteins function within the cell and use this information to develop more suitable drugs. Our group utilizes an extremely powerful X-ray Free Electron Laser (XFEL) to study protein dynamics on very fast time scales. We are particularly interested in studying dynamic systems involving biologically important drug targets.
Recent Publications William J. Bauer, Amit Luthra, Guangyu Zhu, Justin D. Radolf, Michael G. Malkowski, Melissa J. Caimano (2015). Structural characterization and modeling of the Borrelia burgdorferi hybrid histidine kinase Hk1 periplasmic sensor: A system for sensing small molecules associated with tick feeding. J. Struct. Biol., http://dx.doi.org/10.1016/j.jsb.2015.08.013 Wenhua Wang, Alexandre Maucuer, Ankit Gupta, Valérie Manceau, Karen R. Thickman, William J. Bauer, Scott D. Kennedy, Joseph E. Wedekind, Michael R. Green, Clara L. Kielkopf. (2013). Structure of phosphorylated SF1 bound to U2AF65 in an essential splicing factor complex. Structure 21(2), 197–208.3. William J. Bauer, Jason Heath, Jermaine L. Jenkins, Clara L. Kielkopf (2012). Three RNA recognition motifs participate in RNA recognition and structural organization by the pro-apoptotic factor TIA-1. J Mol Biol. 415(4), 727–740. Michael R. Green, Joseph Sambrook (WJB, contributing author) (2012). Expressing Cloned Genes for Protein Production, Purification, and Analysis. Molecular Cloning, 4th Edition, 19, 1481-1703.
William Bauer, PhD
T: 716 898 8620
T: 716 898 8620