My research has focused on the chemistry of metals in biological systems, using crystallography, spectroscopy and computational approaches.  We are involved in developing high-throughput techniques for biophysical characterization and crystallization (www.getacrystal.com).  We are also interested in developing new methods that combine crystallographic and spectroscopic approaches to answer fundamental questions about protein biochemistry.

Select Publications:

Metalloprotein crystallography: More than a structure. Bowman, SEJ, Bridwell-Rabb, J, Drennan, CL.  Acc Chem Res 201649, 695-702.

ACS Editors’ Choice Article

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Featured on journal cover

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Manganese Binding Properties of Human Calprotectin under Conditions of High and Low Calcium: X-ray Crystallographic and Advanced Electron Paramagnetic Resonance Spectroscopic Analysis.  Gagnon, DM, Brophy, MB, Bowman, SEJB, Stich, TA, Drennan, CL, Britt, RD, Nolan, EM.  J Am Chem Soc 2015137, 3004-3016

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Effects of Protein Structure on Iron-Polypeptide Vibrational Dynamic Coupling in Cytochrome c. Galinato, MGI, Bowman, SEJ, Kleingardner, JG, Martin, S, Zhao, JY, Sturhahn, W, Alp, EE, Bren, KL, Lehnert, L. Biochemistry 2015, 54, 1064-1076

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The influence of heme ruffling on porphyrin spin densities in cytochromes c probed by core heme carbon NMR.  Kleingardner, JG, Bowman, SEJ, Bren, KL. Inorg Chem 201352, 12933-12946

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Methionine Ligand Lability in Bacterial Monoheme Cytochromes c: An Electrochemical Study. Levin, BD, Can, M, Bowman, SEJ, Bren, KL, Elliott, SJ. J Phys Chem B 2011115, 11718-11726

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Heme-protein vibrational couplings in cytochromes c provide a dynamic link that connects the heme-iron and the protein surface. Galinato, MGI, Kleingardner, JG, Bowman, SEJ, Alp, EE, Zhao, J, Bren, KL, Lehnert, N. PNAS 2012109, 8896-8900

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Variation and Analysis of Second Sphere Interactions and Axial Histidinate Character in c-type Cytochromes. Bowman, SEJ, Bren, KL. Inorg Chem 2010, 49, 7890-7897

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The Chemistry and Biochemistry of Heme c: Functional Bases for Covalent Attachment. Bowman, SEJ, Bren, KL. Nat Prod Rep 200825, 1118-1130

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