Policies and User Fees

Our goal is to provide access to expertise, equipment and technology to facilitate crystallization of biological macromolecules. We are a non-profit organization and our fee structure has been determined to cover the minimum basic operating expenses of the HTCSC, including supplies, routine maintenance, software, and consumables. The HTCSC provides access to cost-efficient high-throughput crystallization screening experiments for academic and other not-for-profit users.

Pricing as of May 2018
Standard academic and not-for-profit user rates:

  • $400 for set up, imaging and software (billed after the sample has been set up)
    • Make a screening reservation by emailing htscenter@hwi.buffalo.edu by the reservation deadline
    • Complete submission form online
    • You get:
      • 1536 microbatch under oil crystallization screening experiments
      • Email notification and immediate access to color images*
        • Cocktail only, day 1, and at 1, 2, 3, 4 and 6 weeks
      •  Email notification and access to images from a Formulatrix Imager 1000 SONICC and UV-TPEF.*
        • At 4 weeks (23 °C samples) or 6 weeks (4 °C or 14 °C samples
        • *Actual read time may vary slightly and is dependent on availability of the system
      • Software to view, annotate and analyze images and associated chemical data

Subscription academic and not-for-profit user rates:

For academic users needing frequent crystallization screening experiments, we are offering a limited-time subscription program.** Subscriptions are for a 6 month trial period.

  • $1900 for 5 experimental screens
    • Subscribers still need to make a screening reservation and complete the submission form
    • Subscriptions are pre-paid for the 6 month period between May 2018 and October 2018.
  • After 5 screens, the cost per screen for subscribers is $370
    • After the 5 pre-paid screens, additional screens will be billed after the sample has been set up

** We will re-assess the subscription program after a beta-testing period of time.

Additional fees
We can often accommodate special requirements; however, additional services may involve additional fees. Please contact the HTCSC at htscenter@hwi.buffalo.edu for special requests and more details.

Information about samples and users received for crystallization screening will not be publicly disclosed without the written consent of the investigator(s).

The images obtained at the HTCSC may be used for grant applications to support the scientific research of the center, as well as in publications. Images will be de-identified from sample and user information unless consent has been given.

Citing the HTCSC
If the HTCSC assists you in identifying initial crystallization conditions, please reference the appropriate screen and let us know so we can add you to our Structures Solved! list.

• Soluble Screen. Luft, JR, et al. A deliberate approach to screening for initial crystallization conditions of biological macromolecules. J. Struct. Biol. 2003; 142, 170.

• Membrane Screen. Koszelak-Rosenblum, M, et al. Determination and application of empirically derived detergent phase boundaries to effectively crystallize membrane proteins. Protein Science 2009; 18, 1828.

We request that, in the case of the HTCSC screening experiments being offered as part of other expert services through crystallization facilities at other institutions, that the HTCSC is acknowledged and our website www.getacrystal.com is linked on that facility website.

This service is for academic and other not-for-profit users. Commercial users are encouraged to visit our friends at HarkerBIO (www.harkerbio.com).