The Crystallization Center at HWI
NEWS
Apply for the HWI Young Professionals 2024 Program Today!
HWI Young Professionals is a six-session program that engages young professionals focused on building community support for the Hauptman-Woodward Medical Research Institute.
To apply or to learn more, please visit our Young Professionals page or contact Kelly Campbell at kcampbell@hwi.buffalo.edu or (716) 898-8624.
Institute
Structures Magazine
Fall 2023 / Winter 2024 Edition.
NEWS
We’re hiring
Positions available for Scientists, and a Business Development Manager in Buffalo New York. Click here for details.
We offer an excellent benefits package and a welcoming environment that embraces diversity in people as well as the skills they bring to us
RESEARCH
Dr. Paz publishes in Nature Communications
HWI scientist Dr. Aviv Paz was part of a team that published a paper entitled “Membrane potential accelerates sugar uptake by stabilizing the outward-facing conformation of the Na/glucose symporter vSGLT” in the journal Nature Communications. This work with scientists at the University of California Los Angeles and San Francisco has broad implications for transporting numerous chemicals in the body and managing life-threatening conditions like diabetes, heart failure, and kidney failure.
RESEARCH
Dr. Lynch is fighting drug resistance in HIV/AIDS
Around the world, HIV/AIDS continues to be a major health problem. Several treatment regimens have dramatically reduced HIV-related illness and death. HIV-1 protease is one of the critical targets of these regimens. However, this drug target is prone to the development of treatment resistance. HWI scientist Dr. Miranda Lynch and collaborators at the Rochester Institute of Technology recently published this research in Biophysics Reports in a paper entitled Evolution of drug resistance drives destabilization of flap region dynamics in HIV-1 protease.
NEWS
Dr. Snell joins the IUCr Book Series Committee
Dr. Edward Snell, Chief Scientific Officer at Hauptman-Woodward Medical Research Institute (HWI), has been appointed to the International Union of Crystallography (IUCr) Committee as a member of the Book Series Committee. The Committee recommends new book publications to the IUCr Executive Committee and the Delegates of Oxford University Press. Recommended publications are IUCr monographs, which are in-depth expositions of specialized topics in crystallography, crystallography texts providing standardized methods and approaches, and related books.
NEWS
Drs. Keefe and Bowman Elected to US National Committee for Crystallography
We congratulate both Dr. Lisa Keefe for being elected as the new Vice Chair and Dr. Sarah Bowman for being elected as a member of the US National Committee for Crystallography (USNC/Cr).
Research
HWI scientists Miranda Lynch, Elizabeth Snell, Stephen Potter, Edward Snell, and Sarah Bowman published a paper describing crystallization screening at HWI for the worldwide scientific community. The paper entitled 20 years of crystal hits: progress and promise in ultrahigh-throughput crystallization screening was selected as a cover feature.
RESEARCH
Dr. Sarah EJ Bowman and the National Crystallization Center help address the challenge of finding new antimicrobials
HWI has been involved in a large collaborative project resulting in a paper published in Nature Microbiology.
NEWS
Dr. Sarah EJ Bowman and Dr. Miranda L Lynch have received a new $1.57M grant from the National Institutes of Health.
A $1.57M grant from the National Institutes of Health to supports research on detecting and handling small crystals for cutting edge structural biology. Structural characterization of biomolecules important in human health and disease is crucial to understanding how these molecules function, as well as to designing therapeutics. Structural methods that make use of vanishingly small crystals have the potential to revolutionize how we obtain highly detailed structural ‘snapshots’ of biomolecules.
News
HWI staff in Chicago help Pfizer create an effective COVID-19 treatment
Our team at the Advanced Photon Source have helped Pfizer create a COVID-19 treatment. The new drug candidate, Paxlovid, significantly reduced hospitalization and death in adult patients, according to Pfizer, and will be submitted for an emergency use authorization in the United States.
News
The Institute is home to the National Crystallization Center
This Five-year award from NIH brings prestige, jobs, investment to Western New York and recognizes almost two decades of our developments in this area. The National Crystallization Center provides access to state-of-the-art robotic instrumentation, advanced imaging technologies, and expertise in crystallization to the scientific community supporting both academia and industry.
The Center is actively involved in the fight against COVID-19.
Research
Dr. Snell accuratly identifying metals in proteins.
Many proteins contain metals. Accurate identification of these is both a problem and a prerequisite to understanding the biological mechanism and curing disease. An international team co-led by Dr. Snell developed a sensitive method to accurately determine both the metal type and position using very small volumes of protein.
Research
Structural biology at the center of COVID-19 scientific efforts
Synergy between X-ray crystallography, cryoelectron microscopy and computational methods has led to critical advances indispensable to developing treatments for infection and vaccines for prevention.